PF-06250112是一种有效的、高度选择性、口服有效的BTK抑制剂，IC50值为0.5nM，对BMX非受体酪氨酸激酶和TEC同样有抑制作用，IC50值分别为0.9nM和1.2nM。
CAS：1609465-89-5
分子式：C22H20F2N6O2
分子量：438.43
纯度：98%
存储：Store at -20°C

Background:

PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively[1]. IC50: 0.5 nM (BTK), 0.9 nM (BMX), 1.2 nM (TEC)[1]

[1]. Rankin AL, et al. Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis. J Immunol. 2013 Nov 1;191(9):4540-50.