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B220
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
B220图片
CAS NO:112228-65-6
规格:98%
分子量:318.42
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
B220是一种能抑制HSV-1,HSV-2和人巨细胞病毒(CMV)生长的抗病毒剂。
CAS:112228-65-6
分子式:C20H22N4
分子量:318.42
纯度:98%
存储:Store at -20°C

Background:

B220 is an antiviral agent which can inhibit the growth of HSV-1, HSV-2 and human cytomegalovirus (CMV).


B220 is an antiviral agent which can inhibit the growth of HSV-1, HSV-2 and human cytomegalovirus (CMV)[1]. B220 inhibits neutrophil release of reactive oxygen species, as well as intracellular generation of reactive oxygen species. The inhibition is not achieved through direct oxygen radical scavenger activity of B220, and B220 has no immediate effects on the activity of the assembled oxidase. The neutrophil capability to phagocytose fluorescein-labeled opsonized yeast cells is reduced by B220. Cells preincubated with B220 (10 µg/mL) and then stimulated with the formylated peptide fMLP mobilize fewer C3 receptors on their surface than the control cells[2].



[1]. Mohammed Homman, et al. Pharmaceutical formulation of B220 for topical treatment of herpes. EP 2489354 A1. [2]. Harbecke O, et al. The synthetic non-toxic drug 2,3-dimethyl-6(2-dimethylaminoethyl)-6H-indolo-(2,3-b)quinoxaline inhibits neutrophil production of reactive oxygen species. J Leukoc Biol. 1999 Jun;65(6):771-7.