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Loxiglumide(CR-1505)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Loxiglumide(CR-1505)图片
CAS NO:107097-80-3
规格:98%
分子量:461.38
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Loxiglumide是缩胆囊素(CCK-1)受体拮抗剂。
CAS:107097-80-3
分子式:C21H30Cl2N2O5
分子量:461.38
纯度:98%
存储:Store at -20°C

Background:

Loxiglumide is a cholecystokinin (CCK-1) receptor antagonist.



The effects of pancreatic rest by oral administration of CCK-1 receptor antagonist Loxiglumide and pancreas stimulation are investigated via endogenous CCK release induced by po protease inhibitor camostat on the recovery of pancreatic secretory function, and biochemical and histological changes of the pancreas after acute hemorrhagic pancreatitis. Oral administration of CCK-1 receptor antagonist Loxiglumide with a dose of 50 mg/kg body weight inhibits pancreatic exocrine secretion for more than 12 h. Thus, every 12-h administration of Loxiglumide might have completely blocks the effect of endogenously released CCK on the pancreas (pancreatic rest)[1].


[1]. Jia D, et al. Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats. World J Gastroenterol. 2015 Jul 7;21(25):7742-53.