LoureirinA是从龙血树中分离到的黄酮类物质，能够降低Akt的磷酸化，具有抗血小板聚集的作用。
CAS：119425-89-7
分子式：C17H18O4
分子量：286.32
纯度：98%
存储：Store at -20°C

Background:

Loureirin A is a flavonoid extracted from Dragon’s Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.

Loureirin A (50 μM, 100 μM) inhibits collagen-induced platelet ATP secretion and thrombin-stimulated P-selectin expression in a dose-dependent manner. Loureirin A also significantly impairs platelet spreading on immobilized fibrinogen. Loureirin A almost completely eliminates collagen-induced Akt phosphorylation at Ser473 at the dose of 100 μM, and has an additive inhibitory effect with the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets at 50 μM[1].

[1]. Hao HZ, et al. Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies. Eur J Pharmacol. 2015 Jan 5;746:63-9.