Toringin，是一种从 Docyniopsis tschonoski 的树皮中分离出来的生物类黄酮。 Toringin 不仅逐渐降低扩增的 CTG 重复顺式效应，而且还降低细胞毒性。 暴露于异樱花素 (isosakuranetin)，Toringin 保护 PC12 神经细胞。 类黄酮化合物能够改善由扩增的 CTG 重复引起的功能RNA增加，并且对癌症，冠心病以及其他病症产生有益的作用。
CAS：1329-10-8
分子式：C21H20O9
分子量：416.38
纯度：98%
存储：Store at -20°C

Background:

Toringin, a bioflavonoid, is isolated from the bark of Docyniopsis tschonoski. Toringin progressively decreases not only the cis-effect of the expanded CTG repeats but cytotoxicity as well. Exposure to isosakuranetin, Toringin rescues PC12 neuronal cells. Flavonoids are efficacious for ameliorating the RNA gain of function caused by expanded CTG repeats, and have various biological activities and beneficial actions against cancers, coronary heart disease, among other pathologies[1].

[1]. Furuya H, et al. Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant. Biochem Pharmacol. 2005 Feb 1;69(3):503-16.