Mcl1-IN-9 是一种有效的髓细胞白血病基因 1 (Mcl-1) 抑制剂，在重组的 BCR-ABL+ B-ALL 细胞中的 IC50 值为 446 nM，Ki 值为 0.03 nM。
CAS：1810769-31-3
分子式：C37H39ClN4O4
分子量：639.18
纯度：98%
存储：Store at -20°C

Background:

Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1]. Mcl-1|0.03 nM (Ki)

Mcl1-IN-9 inhibits growth of Mcl-1 dependent tumor cell lines in the nanomolar range[1].

Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses[1].

[1]. Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62(8):3971-3988.