ERK5-IN-1是一种有效的ERK5抑制剂，IC50为87±7nM。ERK5-IN-1也抑制LRRK2[G2019S]，IC50为26nM。
CAS：1234479-76-5
分子式：C25H29N7O2
分子量：459.54
纯度：98%
存储：Store at -20°C

Background:

ERK5-IN-1 is a potent ERK5 inhibitor with an IC50 of 87±7 nM. ERK5-IN-1 also inhibits LRRK2[G2019S] with an IC50 of 26 nM.

ERK5-IN-1 (Compound 5) exhibits a cellular EC50 for inhibiting epidermal growth factor (EGF) induced ERK5 autophosphorylation of 0.19±0.04 μM[1].

[1]. Deng X, et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. Eur J Med Chem. 2013;70:758-767.