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Glycycoumarin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glycycoumarin图片
CAS NO:94805-82-0
规格:98%
分子量:368.38
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Glycycoumarin 是一种甘草中主要的生物活性香豆素。Glycycoumarin 通过激活自噬,抑制内质网应激介导的 JNK 和 GSK-3 介导的线粒体途径,来抑制肝细胞脂性凋亡。Glycycoumarin 能直接靶向 T-LAK 细胞源蛋白激酶发挥抗肝癌活性 。
CAS:94805-82-0
分子式:C21H20O6
分子量:368.38
纯度:98%
存储:Store at -20°C

Background:

Glycycoumarin is a major bioactive coumarin of licorice. Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress-mediated JNK and GSK-3-mediated mitochondrial pathway. Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase [1] [2].




[1]. Zhang E, et al. Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-mediated mitochondrial pathway. Sci Rep. 2016 Nov 30;6:38138. [2]. Song X, et al. Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase. Oncotarget. 2016 Oct 4;7(40):65732-65743.