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Chlorotrianisene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Chlorotrianisene图片
CAS NO:569-57-3
规格:98%
分子量:380.86
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
Estrogen agonist
CAS:569-57-3
分子式:C23H21ClO3
分子量:380.86
纯度:98%
存储:Store at -20°C

Background:

Description:


ED50: 2.0 μM


Glandular kallikrein, a trypsin-like serine protease, has been identified as a major estrogen-induced protein in the rat anterior pituitary. This induction appears to be mediated by increased gene expression since glandular kallikrein mRNA is also estrogen-induced. Chlorotrianisene is classified as an estrogen agonist.


In vitro: The ED50 of chlorotrianisene were lowered by 3.9-fold. Chlorotrianisene inhibited the growth of both P388 and P388/ADR cells in a concentration-dependent manner [1].


In vivo: Chlorotrianisene markedly varied in its ability to elicit agonist responses on the three measures. On uterine weight and anterior pituitary prolactin, chlorotrianisene behaved as partial agonists. Chlorotrianisene also exhibited strikingly less agonist activity on glandular kallikrein than on PRL or the uterus. Further, the small agonist activity of chlorotrianisene on glandular kallikrein induction differed from that on the uterus or prolactin [2].


Clinical trial: Chlorotrianisene is a estrogen which is highly effective in the suppression of postpartum lactation when given orally in dosage of 48 mg/day for seven days. Recurrence of symptoms and appearance of withdrawal bleeding are virtually eliminated, probably because of the storage of chlorotrianisene in the body fat and its gradual release after cessation of therapy [3].


Reference:
[1] Ramu A, Glaubiger D, Fuks Z.  Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by tamoxifen and other triparanol analogues. Cancer Res. 1984 Oct;44(10):4392-5.
[2] Powers CA, Hatala MA, Pagano PJ.  Differential responses of pituitary kallikrein and prolactin to tamoxifen and chlorotrianisene. Mol Cell Endocrinol. 1989 Sep;66(1):93-100.
[3] NULSEN RO, CARMON WB, HENDRICK HO.  TACE (chlorotrianisene), a new estrogen for inhibition of lactation. Am J Obstet Gynecol. 1953 May;65(5):1048-51.
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