| CAS NO: | 99291-25-5 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| Molecular Weight (MW) | 236.31 |
|---|---|
| Formula | C13H20N2O2 |
| CAS No. | 99291-25-5 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 47 mg/mL (198.9 mM) |
| Water: 15 mg/mL (63.5 mM) | |
| Ethanol: 47 mg/mL (198.9 mM) | |
| Other info | Chemical Name: (S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol InChi Key: PTVWPYVOOKLBCG-ZDUSSCGKSA-N InChi Code: InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1 SMILES Code: OC[C@@H](O)CN1CCN(C2=CC=CC=C2)CC1 |
| Synonyms | (S)-(-)-Dropropizine; DF-526; Levodropropizine; DF 526; DF526; Levotuss |
| In Vitro | In vitro activity: Levodropropizine has affinity for H1-histaminic and alpha-adrenergic receptors. |
|---|---|
| In Vivo | Levodropropizine has weaker central sedative effects than the racemate and it does not induce physical dependence in rats. Levodropropizine (15 mg/kg, i.v.) reduces both the duration of apnoea and the response of the C-fibre to phenylbiguanide. The LVDP-induced inhibition of the C-fibre response to PBG is on average 50% in pulmonary and 25% in non-pulmonary fibres. Levodropropizine is shown to have good antitussive activity in anaesthetized guinea-pigs and rabbits. Levodropropizine (i.v.) is 1/10 to 1/20 as active as codeine and comparable to dropropizine on mechanically and electrically induced coughing in rabbits and guinea-pigs. Levodropropizine (orally) is comparable with those of both dropropizine and codeine against coughing induced by irritant aerosols. Levodropropizine (40 μg/50 μL i.c.v.) does not prevent electrically-induced cough, while Codeine (5 μg/50 μl i.c.v.) markedly prevents coughing in guinea-pigs. Levodropropizine has a peripheral site of action which is related to sensory neuropeptides. Levodropropizine (10 mg/kg, 50 mg/kg and 200 mg/kg) reduces in a dose-dependent manner the extravasation of Evans blue dye evoked by capsaicin in the rat trachea. Levodropropizine (200 mg/kg) inhibits also substance P-evoked extravasation, whereas it does not affect the extravasation evoked by platelet activating factor. |
| Animal model | Rats |
| Formulation & Dosage | 15 mg/kg, 10 mg/kg, 50 mg/kg and 200 mg/kg; i.v. |
| References | Arzneimittelforschung. 1988 Aug;38(8):1144-50; Br J Pharmacol. 1996 Mar;117(5):853-8. |
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