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SB525334
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SB525334图片
CAS NO:356559-20-1
规格:98%
分子量:343.42
包装与价格:
包装价格(元)
5mg电议
25mg电议
100mg电议

产品介绍
(TGF-beta1) receptor inhibitor
CAS:356559-20-1
分子式:C21H21N5
分子量:343.42
纯度:98%
存储:Store at -20°C

Background:

SB525334 is a potent inhibitor of transforming growth factor-beta1 (TGF-beta1) receptor, activin receptor-like kinase (ALK5). It specifically inhibits ALK5 with IC50 value of 14.3nM, which shows 4-fold higher potency against ALK4 [1].


SB525334 has been demonstrated to reduce smad2/3 nuclear fluorescence induced by TGF-beta1 in human renal proximal tubule epithelial (RPTE) cells. Additionally, SB525334 inhibits TGF-beta1 mediated procollagen and PAI-1 expression in human renal carcinoma cells A498 [1].


SB525334 dose-dependently reduces Urinary protein, procollagen alpha1(I) mRNA and procollagen alpha1(III) mRNA when administered orally in acute puromycin aminonucleoside (PAN) rat model of renal disease [1].


Reference:
[1] Grygielko ET1, Martin WM, Tweed C, Thornton P, Harling J, Brooks DP, Laping NJ.  Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. J Pharmacol Exp Ther. 2005 Jun;313(3):943-51.