Befloxatone, formerly known as MD-370503, is a potent, selective and reversible inhibitor of monoamine oxidase A. Befloxatone inhibited selectively and competitively monoamine oxidase (MAO)-A in human and rat brain, heart, liver and duodenum homogenates with Kis ranging from 1.9 to 3.6 nM for MAO-A and from 270 to 900 nM for MAO-B. In vitro, befloxatone was more potent at inhibiting MAO-A activity than reference compounds (befloxatone > harmaline > brofaromine > BW 137OU87 > RS 8359 > toloxatone > moclobemide). References: Zanotti-Fregonara P, Bottlaender M. [11C]befloxatone distribution is well correlated to monoamine oxidase A protein levels in the human brain. J Cereb Blood Flow Metab. 2014 Dec;34(12):1951-2. doi: 10.1038/jcbfm.2014.157. Epub 2014 Sep 17. PubMed PMID: 25227605; PubMed Central PMCID: PMC4269741.

纯度：≥98%

CAS：134564-82-2