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bpV(phen)(potassium hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
bpV(phen)(potassium hydrate)图片
CAS NO:171202-16-7
规格:98%
分子量:404.3
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM).
CAS:171202-16-7
分子式:C12H8N2O5V.K+(H2O)3
分子量:404.3
纯度:98%
存储:Store at -20°C

Background:

bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 343 nM), and PTP-1β (IC50 = 920 nM). At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5’-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.