CAS NO: | 83881-52-1 |
规格: | ≥98% |
包装 | 价格(元) |
500mg | 电议 |
1g | 电议 |
2g | 电议 |
5g | 电议 |
10g | 电议 |
25g | 电议 |
Molecular Weight (MW) | 461.81 |
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Formula | C21H25ClN2O3.2HCl |
CAS No. | 83881-52-1 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: 92 mg/mL (199.2 mM) |
Water: 92 mg/mL (199.2 mM) | |
Ethanol: <1 mg/mL | |
Solubility (In vivo) | Chemical Name: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride InChi Key: PGLIUCLTXOYQMV-UHFFFAOYSA-N InChi Code: InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H SMILES Code: C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl |
Synonyms | UCB-P071; P071; UCBP071; P-071; P 071; UCB P071; Cetirizine Hydrochloride; Reactine; Zyrtec; Alerlisin; Cetirizine Dihydrochloride |
In Vitro | In vitro activity: Cetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients with atopic dermatitis. The levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. Cetirizine dihydrochloride, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. Cetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients with atopic dermatitis. The levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. |
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In Vivo | Cetirizine (20 mg/kg, mice, orally) exerts its anti-inflammatory effects by inhibiting MIF as well as IL-8 production in mice immunized and challenged with ragweed pollen. |
Animal model | Mice |
Formulation & Dosage | 20 mg/kg, oral |
References | Pharmacology. 2013;92(1-2):14-25; Allergy Proc. 1991 May-Jun;12(3):187-91. |