CAS NO: | 108929-04-0 |
规格: | ≥98% |
包装 | 价格(元) |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
1g | 电议 |
2g | 电议 |
Molecular Weight (MW) | 285.77 |
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Formula | C16H15N3.HCl |
CAS No. | 108929-04-0 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: 57 mg/mL (199.5 mM) |
Water: N/A | |
Ethanol: 57 mg/mL (199.5 mM) | |
Solubility (In vivo) | Chemical Name:
3-Amino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine Hydrochloride InChi Key: VKXSGUIOOQPGAF-UHFFFAOYSA-N InChi Code: InChI=1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H SMILES Code: C1C2C3=CC=CC=C3CC4=CC=CC=C4N2C(=N1)N.Cl |
Synonyms | WAL-801CL HCl; WAL801CL HCl; Alesion; Elestat; Epinastine HCl; Epinastin HCl; WAL 801CL HCl; WAL-801-CL HCl; Epinastine Hydrochloride; |
In Vitro | In vitro activity: Epinastine shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum. Epinastine is able to displace specific [3H]NC-5Z binding at low concentrations in the locust nervous tissue. Epinastine binds to the honey bees neuronal octopamine receptor with Ki of 1.1 nM. Epinastine antagonises octopamine-induced cAMP formation in the insect brain. Epinastine causes an inhibition of histamine release from rat peritoneal mast cells induced by both antigen-antibody reaction and compound 48/80. Epinastine is similarly effective in inhibiting compound 48/80-induced histamine release not only from isolated rat peritoneal mast cells but also from rat mesenterial pieces. Epinastine is effective in inhibiting not only Ca2+ uptake into lung mast cells in actively sensitized guinea pigs but also Ca2+ release from the intracellular Ca store of rat peritoneal mast cells exposed to both compound 48/80 and substance P. Epinastine shows a dose- and time-dependent suppressive effect on IL-8, one of the chemokines for eosinophils, released from eosinophils isolated from atopic diseases. |
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In Vivo | Epinastine inhibits histamine-induced reactions in the skin or the lung of rats, dogs and guinea pigs. |
Animal model | |
Formulation & Dosage | |
References | J Pharmacol Exp Ther. 1997 Apr;281(1):233-44; Drugs. 1996;52 Suppl 1:15-9; Drugs. 1996;52 Suppl 1:8-14. |