MRL-871 is a RORγt inhibitor, binding to a previously unidentified allosteric pocket in the RORγt LBD. References: Scheepstra M, Leysen S, van Almen GC, Miller JR, Piesvaux J, Kutilek V, van Eenennaam H, Zhang H, Barr K, Nagpal S, Soisson SM, Kornienko M, Wiley K, Elsen N, Sharma S, Correll CC, Trotter BW, van der Stelt M, Oubrie A, Ottmann C, Parthasarathy G, Brunsveld L. Identification of an allosteric binding site for RORγt inhibition. Nat Commun. 2015 Dec 7;6:8833. doi: 10.1038/ncomms9833. PubMed PMID: 26640126; PubMed Central PMCID: PMC4686831.

纯度：≥98%

CAS：1392809-08-3