Banoxantrone (AQ4N) is a novel and potent bio-reductive prodrug that can be reduced under hypoxic conditions (hypoxia-activated) to a stable, DNA-affinic compound AQ4 (CAS#: 70476-63-0), which is a potent topoisomerase II inhibitor with anticanceractivity. Banoxantrone intercalates into and crosslinks DNA, and inhibits topoisomerase II. This results in an inhibition of DNA replication and repair in tumor cells. Combined with conventional therapeutic agents, both oxygenic and hypoxic regions of tumors can be targeted.

纯度：≥98%

CAS：136470-65-0