Description: MRT-68921 HCl, the hydrochloride salt of MRT68921, is a dual inhibitor of ULK1 and ULK2 (the autophagy kinases) with potential anticancer activity. It inhibits ULK1/2 with IC50s of 2.9 and 1.1 nM, respectively. MRT68921 significantly kills tumor cells by breaking the balance of oxidative stress signals. These results highlight the potential of MRT68921 as an effective agent for tumor therapy.

References:

1. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.

2. cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53. Oncotarget. 2018 Jul 13;9(54):30434-30449.
   

Related CAS #: 1190379-70-4 (free base) 2080306-21-2 (HCl) 2070014-87-6

纯度：≥98%

CAS：2080306-21-2