MTC420 is a anti-tuberculosis agent. MTC420 exhibits acceptable anti-tuberculosis activity (Mtb IC50 =525 nM, Mtb Wayne IC50 = 76 nM and MDR Mtb patient isolates IC50 = 140 nM) and favourable pharmacokinetic and toxicological profiles. References: Hong WD, Gibbons PD, Leung SC, Amewu R, Stocks PA, Stachulski AV, Horta PC, Cristiano ML, Shone AE, Moss D, Ardrey A, Sharma R, Warman AJ, Bedingfield PT, Fisher NE, Aljayyoussi G, Mead S, Caws M, Berry NG, Ward SA, Biagini GA, O'Neill PM, Nixon GL. Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis. J Med Chem. 2017 Mar 17. doi: 10.1021/acs.jmedchem.6b01718. [Epub ahead of print] PubMed PMID: 28304162.

纯度：≥98%

CAS：2088930-66-7