N-(Propargyl-PEG4)-biocytin is a PEG-based linker used in the synthesis of PROTACs. It is a biotin PEG analogue containing a carboxylic group and an alkyne group. Reaction of carboxylic with primary amino (-NH2) forms stable, irreversible (covalent) amide bonds. The alkyne group can react with azide moiety in Cu(I)-catalyzed Click Chemistry reaction to form a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media and increases membrane impermeability of the molecules conjugated to the biotin compound.

纯度：≥98%

CAS：2055042-71-0