Nitidine is a benzophenanthridine alkaloid found in species of the genus Zanthoxylum , notably in Zanthoxylum nitidum. This compound has an anti-malarial activity. Nitidine increased CNS tissue sparing and improved functional recovery by attenuating reactive microgliosis, suggestive of the potential therapeutic benefit for CNS injury. Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer. Nitidine chloride inhibits renal cancer cell metastasis via suppressing AKT signaling pathway. Nitidine chloride inhibits ovarian cancer cell migration and invasion by suppressing MMP-2/9 production via the ERK signaling pathway. Nitidine chloride induces apoptosis, cell cycle arrest, and synergistic cytotoxicity with doxorubicin in breast cancer cells. References: Yuan Y, Zhu F, Pu Y, Wang D, Huang A, Hu X, Qin S, Sun X, Su Z, He C. Neuroprotective effects of nitidine against traumatic CNS injury via inhibiting microglia activation. Brain Behav Immun. 2015 Aug;48:287-300. doi: 10.1016/j.bbi.2015.04.008. PubMed PMID: 25900440.

纯度：≥98%

CAS：13063-04-2