Napamezole, formerly known as WIN-51181, is an α2 adrenergic receptor antagonist potentially for the treatment of major depressive disorder and anxiety. Napamezole reversed clonidine-induced decreased in twitch height in the electrically stimulated rat vas deferens. Napamezole also antagonized methoxamine-induced contractions (alpha-1) of the rat vas deferens with a Kb of 135 nM. References: Cordi AA, Berque-Bestel I, Persigand T, Lacoste JM, Newman-Tancredi A, Audinot V, Millan MJ. Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties. J Med Chem. 2001 Mar 1;44(5):787-805. PubMed PMID: 11262089.

纯度：≥98%

CAS：91524-14-0