ND-322 HCl is a selective MT1-MMP/MMP2 inhibitor. MT1-MMP and MMP2 have been implicated as pro-tumorigenic and pro-metastatic factors in a wide variety of cancers including melanoma. ND-322 HCl reduces melanoma tumor growth and delays metastatic dissemination. References: Meisel JE, Chang M. Selective small-molecule inhibitors as chemical tools to define the roles of matrix metalloproteinases in disease. Biochim Biophys Acta. 2017 Nov;1864(11 Pt A):2001-2014. doi: 10.1016/j.bbamcr.2017.04.011. Epub 2017 Apr 20. Review. PubMed PMID: 28435009.

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CAS：1333379-23-9