AVL-3288 (UCI-4083; UCI4083; CCMI; XY-4083; Anvylic-3288; AVL3288) is an orally bioavailable and selective allosteric modulator of the α7 nicotinic acetylcholine receptor (α7 nAChR) with neuroprotective effects. AVL-3288 showed preclinical efficacy in rat paradigms of attention and memory, including models of cognitive dysfunction1-3. AVL-3288 evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). AVL-3288 exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.

纯度：≥98%

CAS：917837-54-8