| CAS NO: | 318-98-9 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 25g | 电议 |
| 50g | 电议 |
| Molecular Weight (MW) | 295.8 |
|---|---|
| Formula | C16H21NO2.HCl |
| CAS No. | 318-98-9 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 59 mg/mL (199.5 mM) |
| Water: 6 mg/mL (20.3 mM) | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: 1-Naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol hydrochloride InChi Key: ZMRUPTIKESYGQW-UHFFFAOYSA-N InChi Code: InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H SMILES Code: OC(CNC(C)C)COC1=C2C=CC=CC2=CC=C1.[H]Cl |
| Synonyms | AY-64043, ICI-45520, NCS-91523; AY 64043, ICI 45520, NCS 91523; AY64043, ICI45520, NCS91523; |
| In Vitro | In vitro activity: Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. |
|---|---|
| In Vivo | Propranolol hydrochloride (orally administration; 40 mg/kg; daily) significantly reduces the vessel diameter relative to the vehicle-treated implants, and increases the number of cells that expressed phosphorylated ERK1/2 within the IH Matrigel implant |
| Animal model | Mouse model of IH (infantile hemangiomas) with HemSC cells |
| Formulation & Dosage | 40 mg/kg; oral |
| References | [1]. Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. Epub 2006 Aug 1 [2]. Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73. [3]. Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. [4]. Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55. |
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