Normirtazapine (ORG-3838; ORG3838; ORG 3838) is a N-demethylated metabolite of mirtazapine (Zispin; Remeron; Avanza), which is a 5-HT2/3 receptor inhibitor and noradrenergic and specific
serotonergic antidepressant (NaSSA) approved in 1990 atypical
antidepressant for the
treatment of depression.