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Adrenalone HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Adrenalone HCl图片
CAS NO:62-13-5
规格:≥98%
包装与价格:
包装价格(元)
1g电议
2g电议
5g电议
10g电议
25g电议
50g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)217.65
FormulaC9H11NO3.HCl
CAS No.62-13-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 44 mg/mL (202.2 mM)
Water: 44 mg/mL (202.2 mM)
Ethanol: <1 mg/mL
Other info

Chemical Name: 1-(3,4-dihydroxyphenyl)-2-(methylamino)ethan-1-one hydrochloride

InChi Key: CSRRBDMYOUQTCO-UHFFFAOYSA-N

InChi Code: 1S/C9H11NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,10-12H,5H2,1H3;1H

SMILES Code: C(c1cc(O)c(cc1)O)(CNC)=O.Cl

Synonyms

Adrenalone hydrochloride, Adrenone hydrochloride, Adrenalonium chloratum, Adrenone HCl, Epinephrine ketone hydrochloride, Kephrine hydrochloride, Stryphnonasal

实验参考方法
In Vitro

In vitro activity: Adrenalone (12 μM) inhibits conversion of dopamine to norepinephrine by inhibiting dopamine β oxidase. The structure of Adrenalone differs from epinine only in that the former possesses a ketone group in the β position. The reduction of adrenalone (0.1 mM) by hydrated electrons in nitrogenated aqueous solutions containing either 10 or 100 mM tert-butyl alcohol results in identical transient spectra, therefore all OH radicals have been scavenged. While adrenalone behaves like a carbonyl compound during reduction, oxidation reactions are primarily governed by the catechol functional group. Adrenalone, which is a topical nasal decongestant, hemostatic, and vasoconstrictor, is a keton form of the natural substrate epinephrine. Adrenalone contains an aromatic ring that forms hydrophobic interactions with Phe72, Tyr152, and Phe317, an amine group that forms an ionic bond with Asp75, and a hydroxyl group that forms a hydrogen bond with Ala145. Adrenalone at 10 μM (100 μM) reduces substrate uptake to 99% (27%).

In VivoAdrenalone (0.05%) administrated topically to the eyes of rabbits at 30 min intervals results in concentration of 7.75 mg/kg, 0.87 mg/kg and 2.51 mg/kg in cornea, aqueous humor and iris-ciliary body, respectively.
Animal modelRabbits
Formulation & Dosage7.75 mg/kg, 0.87 mg/kg and 2.51 mg/kg; administrated topically
References

Nature. 1961 Dec 16;192:1081; Exp Eye Res. 1984 Jun;38(6):621-6.