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2BAct
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2BAct图片
CAS NO:2143542-28-1
规格:≥98%
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍

2BAct is a novel, potent, highly selective, CNS-permeable, and orally bioactive eif2b (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM, it prevents neurological defects caused by a chronic integrated stress response (ISR). Long-term treatment with 2BAct prevents all measures of pathology and normalizes the transcriptome and proteome of Vanishing White Matter (VWM) mice. 2BAct stimulates the remaining activity of mutant eIF2B complex in vivo, abrogating the maladaptive stress response. Thus, 2BAct-like molecules may provide a promising therapeutic approach for VWM and provide relief from chronic ISR induction in a variety of disease contexts.

纯度:≥98%

CAS:2143542-28-1