Argatroban hydrate (also known as MD-805; MCI-9038; Argipidine) is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM. Argatroban is used as an anticoagulant that acts as a direct thrombin inhibitor. Argatroban was approved by FDA in 2000 for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT). As a direct thrombin inhibitor, Argatroban reversibly binds to the thrombin active site. Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions which include fibrin formation, activation of coagulation factors V, VIII, and XIII; activation of protein C, and platelet aggregation as well.

纯度：≥98%

CAS：141396-28-3