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Ono 6240
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:99659-62-8
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

Ono 6240 is a platelet-activating factor antagonist. Studies suggest that Ono 6240 prevented airway eosinophilia by inhibiting production of IL-5 and IL-2 (Interleukin Levels). Results suggested that ONO-6240 may be of value in treating human asthmatic patients. References: Shi H, Xu H, Liang G. [Effects of a platelet-activating factor antagonist ONO-6240 on antigen induced eosinophil infiltration into the airways]. Zhonghua Nei Ke Za Zhi. 1995 Nov;34(11):753-6. Chinese. PubMed PMID: 8731847. 2: Ando M, Suginami H, Matsuura S. Pregnancy suppression by a platelet activating factor antagonist, ONO-6240, in mice. Asia Oceania J Obstet Gynaecol. 1990 Jun;16(2):169-74. PubMed PMID: 2378595. 3: Toyofuku T, Kubo K, Kobayashi T, Kusama S. Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep. Prostaglandins. 1986 Feb;31(2):271-81. PubMed PMID: 3754344. 4: Hwang SB, Lam MH. Species difference in the specific receptors of platelet activating factor. Biochem Pharmacol. 1986 Dec 15;35(24):4511-8. PubMed PMID: 3024653. 5: Terashita Z, Imura Y, Takatani M, Tsushima S, Nishikawa K. CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. J Pharmacol Exp Ther. 1987 Jul;242(1):263-8. PubMed PMID: 3612533. 6: Hsueh W, Gonzalez-Crussi F, Arroyave JL, Anderson RC, Lee ML, Houlihan WJ. Platelet activating factor-induced ischemic bowel necrosis: the effect of PAF antagonists. Eur J Pharmacol. 1986 Apr 9;123(1):79-83. PubMed PMID: 3754817. 7: Hakugawa J, Bae SJ, Vinuesa MA, Tanaka Y, Katayama I. [The inhibitory effect of LTB4 antagonist on eosinophil infiltration in cutaneous and gut late phase response in BALB/C mice sensitized with ovalubumin (OVA)]. Arerugi. 1997 Jan;46(1):42-8. Japanese. PubMed PMID: 9078611. 8: Hwang SB. Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes. J Biol Chem. 1988 Mar 5;263(7):3225-33. PubMed PMID: 2830276. 9: Mikami T, Fukushi K, Ishitani M, Ishitani K, Suzuki S, Suzuki M. Induction of platelet-activating factor in mice by intravenous administration of a neutral fraction of bakers' yeast mannan. Lipids. 1991 Dec;26(12):1404-7. PubMed PMID: 1819741. 10: Tokumura A, Yoshida J, Maruyama T, Fukuzawa K, Tsukatani H. Platelet aggregation induced by ether-linked phospholipids. 1. Inhibitory actions of bovine serum albumin and structural analogues of platelet activating factor. Thromb Res. 1987 Apr 1;46(1):51-63. PubMed PMID: 3647677. 1 Hwang SB. Specific receptor sites for platelet activating factor on rat liver plasma membranes. Arch Biochem Biophys. 1987 Sep;257(2):339-44. PubMed PMID: 2821908. 12: Hirafuji M, Shinoda H. Platelet-leukocyte interaction in adhesion to endothelial cells induced by platelet-activating factor in vitro. Br J Pharmacol. 1991 Jun;103(2):1333-8. PubMed PMID: 1884095; PubMed Central PMCID: PMC1908373. 13: Paulson SK, Wolf JL, Novotney-Barry A, Cox CP. Pharmacologic characterization of the rabbit neutrophil receptor for platelet-activating factor. Proc Soc Exp Biol Med. 1990 Nov;195(2):247-54. PubMed PMID: 2172997. 14: Redl H, Vogl C, Schiesser A, Paul E, Thurnher M, Bahrami S, Schlag G. Effect of the PAF antagonist BN 52021 in ovine endotoxin shock. J Lipid Mediat. 1990;2 Suppl:S195-201. PubMed PMID: 2133282. 15: Tokumura A, Yoshida J, Okasaka N, Fukuzawa K, Tsukatani H. Platelet aggregation induced by ether-linked phospholipids. 2. Mechanism of desensitization of rabbit platelets by platelet activating factor and reversibility of inhibitory actions of its antagonists. Thromb Res. 1987 Apr 1;46(1):153-61. PubMed PMID: 3590110. 16: Tokumura A, Tsukatani H. [Antagonists of platelet activating factor]. Seikagaku. 1985 Dec;57(12):1618-23. Review. Japanese. PubMed PMID: 3009656. 17: Ohtsuka T, Hiura M, Ozawa M, Okamura N, Ishibashi S. Synergism between platelet-activating factor and diacylglycerol in the induction of superoxide anion production in guinea pig polymorphonuclear leukocytes. Arch Biochem Biophys. 1990 May 15;279(1):21-4. PubMed PMID: 2159756. 18: Hirafuji M, Shinoda H. Antagonism of platelet-activating factor-induced increase in cytosolic free calcium concentration in human endothelial cells. Jpn J Pharmacol. 1992 Mar;58(3):231-41. PubMed PMID: 1513073. 19: Noguchi K, Morita I, Murota S. The detection of platelet-activating factor in inflamed human gingival tissue. Arch Oral Biol. 1989;34(1):37-41. PubMed PMID: 2783040.

纯度:≥98%

CAS:99659-62-8