Aptazapine, formerly known as CGS 7525A, is a tetracyclic antidepressant (TeCA) which was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. It is a potent α2-adrenergic receptor antagonist with ~10x the strength of the related compound mianserin and has also been shown to act as a 5-HT2 receptor antagonist and H1 receptor inverse agonist, while having no significant effects on the reuptake of serotonin or norepinephrine. Based on its pharmacological profile, aptazapine may be classified as a noradrenergic and specific serotonergic antidepressant (NaSSA). References: Cirilli R, Orlando V, Ferretti R, Turchetto L, Silvestri R, De Martino G, La Torre F. Direct HPLC enantioseparation of chiral aptazepine derivatives on coated and immobilized polysaccharide-based chiral stationary phases. Chirality. 2006 Aug;18(8):621-32. PubMed PMID: 16715514.

纯度：≥98%

CAS：71576-41-5