PD 138142 is a water soluble inhibitor of ACAT. Triacylglycerol secretion is decreased in the presence of PD-138142-15. References: Carr TP, Hamilton RL Jr, Rudel LL. ACAT inhibitors decrease secretion of cholesteryl esters and apolipoprotein B by perfused livers of African green monkeys. J Lipid Res. 1995 Jan;36(1):25-36. PubMed PMID: 7706945. 2: Wolfgang GH, Robertson DG, Welty DF, Metz AL. Hepatic and adrenal toxicity of a novel lipid regulator in beagle dogs. Fundam Appl Toxicol. 1995 Jul;26(2):272-81. PubMed PMID: 7589916. 3: Robertson DG, Krause BR, Welty DF, Wolfgang GH, Graziano MJ, Pilcher GD, Urda E. Hepatic microsomal induction profile of carbamic acid [[2,6-bis(1- methylethyl)phenoxy] sulfonyl]-2,6-bis(1-methylethyl) phenyl ester, monosodium salt (PD138142-15), a novel lipid regulating agent. Biochem Pharmacol. 1995 Mar 15;49(6):799-808. PubMed PMID: 7702638. 4: Diczfalusy MA, Bjorkhem I, Einarsson K, Alexson SE. Acyl-coenzyme A:cholesterol O-acyltransferase is not identical to liver microsomal carboxylesterase. Arterioscler Thromb Vasc Biol. 1996 Apr;16(4):606-10. PubMed PMID: 8624784. 5: Kodvawala A, Ghering AB, Davidson WS, Hui DY. Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis. J Biol Chem. 2005 Nov 18;280(46):38592-8. Epub 2005 Sep 14. PubMed PMID: 16166077. 6: Sliskovic DR, Krause BR, Picard JA, Anderson M, Bousley RF, Hamelehle KL, Homan R, Julian TN, Rashidbaigi ZA, Stanfield RL. Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity. J Med Chem. 1994 Mar 4;37(5):560-2. PubMed PMID: 8126693.

纯度：≥98%

CAS：142642-31-7