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Pergolide Mesylate(LY127809)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pergolide Mesylate(LY127809)图片
CAS NO:66104-23-2
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)410.59
FormulaC19H26N2S.CH4O3S
CAS No.66104-23-2 (mesylate);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 10 mg/mL (24.35 mM)
Water: 82 mg/mL (199.71 mM)
Ethanol: <1 mg/mL
Other infoChemical Name: 8-beta-((Methylthio)methyl)-6-propylergoline methanesulfonate
InChi Key: UWCVGPLTGZWHGS-ZORIOUSZSA-N
InChi Code: InChI=1S/C19H26N2S.CH4O3S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21;1-5(2,3)4/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3;1H3,(H,2,3,4)/t13-,16-,18-;/m1./s1
SMILES Code: [H][C@@]1(N(CCC)C[C@H](CSC)C[C@@]12[H])CC3=CNC4=C3C2=CC=C4.CS(=O)(O)=O
SynonymsLY127809; Pergolide methanesulfonate; LY-127809; LY 127809
实验参考方法
In Vitro

In vitro activity: Pergolide mesylate (trade name Permax) is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Pergolide mesylate functions as an agonist at the dopamine D2, D1 and serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors. It may possess agonist activity at other dopamine receptor subtypes as well, similar to cabergoline.

In VivoPergolide mesylate decreases plasma prolactin concentrations. The weak agonist activity of pergolide at D1 receptors somewhat alters its clinical and side effect profile in the treatment of Parkinson's disease. The drug is in decreasing use, as it is reported to be associated with a form of heart disease called cardiac fibrosis. The use of pergolide or cabergoline is associated with a significantly increased risk of newly diagnosed cardiac-valve regurgitation.
Animal model
Formulation & Dosage
ReferencesScience. 1979 Sep 14;205(4411):1151-3; Br Med J (Clin Res Ed). 1983 Apr 9; 286(6372): 1177–1179.