PF-04859989 is a selective, irreversible/co-valent and BBB-penetrant inhibitor of kynurenine amino transferase II (KAT II) with a potential to be used for the treatment of cognitive impairment associated with schizophrenia and other psychiatric disorders. It is cyclic hydroxamic acid identified from a high-throughput screen. PF04859989 acts by forming a covalent adduct with the enzyme cofactor, pyridoxal phosphate (PLP), in the active site. PF-04859989 is capable of reducing brain kynurenic acid by 50% at a dose of 10 mg/kg (sc).

纯度：≥98%

CAS：34783-48-7