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Synephrine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Synephrine图片
CAS NO:94-07-5
规格:≥98%
包装与价格:
包装价格(元)
1g电议
2g电议
5g电议
10g电议
25g电议
50g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)167.21
FormulaC9H13NO2
CAS No.94-07-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 33 mg/mL (197.34mM)
Water: <1 mg/mL
Ethanol: 2 mg/mL (12 mM)
Other info

Chemical Name: (R,S)-1-(4-Hydroxyphenyl)-2-(methylamino)ethanol

InChi Key: YRCWQPVGYLYSOX-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3

SMILES Code: CNCC(O)C1=CC=C(O)C=C1

SynonymsOxedrine; Synephrine (racemate); Synephrine (+/-); (+/-)-Synephrine
实验参考方法
In Vitro

In vitro activity: Synephrine is a compound commonly used for weight loss. Synephrine has gained significant popularity as an alternative to ephedrine. Products containing bitter orange or synephrine are suspected of causing adverse cardiovascular reactions. Synephrine can stimulate glucose consumption (Glut4-dependent glucose uptake) by stimulating AMPK activity, regardless of insulin-stimulated PI3 kinase-Akt activity in L6 skeletal muscle cells.

In VivoSynephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine
Animal modelRats
Formulation & Dosage1 mg/kg; oral gavage
References

Int J Med Sci. 2012;9(7):527-38; Biochem Biophys Res Commun. 2012 Feb 24;418(4):720-4.; Jpn J Pharmacol. 2001 Feb;85(2):183-8.