Amorolfine (Ro 14-4767/002), a topically administered drug available in the form of a nail lacquer, is a potent and broad-spectrum antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts. Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation. Amorolfine is an antifungal showing activity against fungi pathogenic to plants, animals and humans. At 0.2, 2 and 5 micrograms/ml amorolfine did not have any significant inhibitory or enhancing effect on phagocytosis whether following simultaneous addition of blastospores and drug to the neutrophils, prior treatment of neutrophils for 2 h before addition of blastospores or prior treatment of blastospores for 2 h.

纯度：≥98%

CAS：78613-35-1