PF-06462894 is a morpholinopyrimidone mGlu5 (mGlu5 Ki = 6 nM). PF-06462894 possessed favorable properties and a predicted low clinical dose (2 mg twice daily). PF-06462894 did not show any evidence of immune activation in a mouse drug allergy model. PF-06462894 had favorable biopharmaceutical properties, affording projected low daily orally bioavailable doses and a long half-life in humans and was therefore profiled in both rat and NHP studies. References:

纯度：≥98%

CAS：1622291-66-0