PF-06446846 HCL (PF-6446846; PF6446846) is a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor with anti-hyperlipidemic effects. It inhibits the translation of PCSK9 by inducing the ribosome to stall around codon, mediated by the sequence of the nascent chain within the exit tunnel. PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing. PF-06446846 is highly selective for the inhibition of PCSK9 translation. Inhibiting PCSK9 can potentiate CD8 + T cell antitumor activity by promoting LDLR-mediated TCR recycling and signaling. Thus PCSK9/LDLR may serve as a potential target for cancer immunotherapy as well.

纯度：≥98%

CAS：1632250-50-0