PF-06445974 a promising PET lead. PF-06445974 has exquisite potency at PDE4B, good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the “cold tracer” study. In subsequent non-human primate (NHP) PET imaging studies, [18F]PF-06445974 showed rapid brain uptake and high target specificity, indicating that [18F]PF-06445974 is a promising PDE4B-preferring radioligand for clinical PET imaging. References:

纯度：≥98%

CAS：2055776-17-3