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Amonafide L-malate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amonafide L-malate图片
CAS NO:618863-54-0
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍

Description: Amonafide L-malate (NSC308847, AS1413) is an imide analogue of naphthalic acid and a potent topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA. Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Amonafide intercalated with DNA and disrupted the loading of topoisomerases. In contrast to the classic agents, amonafide was found to induce higher molecular weight fragmentation, resulting in the apoptosis without DNA cleavage. Amonafide was found to act in an ATP-independent manner and seemed unlikely to induce the chromosome translocations associated with treatmentinduced leukemia .

References: Cancer Res. 1987 Feb 15;47(4):1040-4; Expert Rev Hematol. 2012 Feb;5(1):17-26.

Related CAS #: 69408-81-7 (free base) 150091-68-2 (2HCl) 618863-54-0 (L-malate) 618863-60-8

纯度:≥98%

CAS:618863-54-0