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MitoEbselen-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MitoEbselen-2图片
CAS NO:1638973-78-0
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍

MitoEbselen-2 (MitoPeroxidase-2), an Ebselen derivative, is a novel and potent radiation mitigator. It can reduce lipid hydroperoxides and prevent cell death due to apoptosis. Upon administration 24 hours after irradiation, MitoEbselen-2 was demonstrated to increase the survival time of mice after exposure to whole body γ-irradiation. Ionizing radiation (IR) triggers mitochondrial overproduction of H2O2 and accumulation of lipid hydroperoxides leading to the induction of apoptotic and necroptotic cell death pathways. Given the high catalytic efficiency of the seleno-enzyme glutathione peroxidase (Gpx) toward reduction of lipid hydroperoxides and H2O2, the potential of MitoEbselen-2, a mitochondria-targeted derivatives of ebselen, to mitigate the deleterious effects of IR was tested.

纯度:≥98%

CAS:1638973-78-0