MitoEbselen-2 (MitoPeroxidase-2), an Ebselen derivative, is a novel and potent radiation mitigator. It can reduce lipid hydroperoxides and prevent cell death due to apoptosis. Upon administration 24 hours after irradiation, MitoEbselen-2 was demonstrated to increase the survival time of mice after exposure to whole body γ-irradiation. Ionizing radiation (IR) triggers mitochondrial overproduction of H₂O₂ and accumulation of lipid hydroperoxides leading to the induction of apoptotic and necroptotic cell death pathways. Given the high catalytic efficiency of the seleno-enzyme glutathione peroxidase (Gpx) toward reduction of lipid hydroperoxides and H₂O₂, the potential of MitoEbselen-2, a mitochondria-targeted derivatives of ebselen, to mitigate the deleterious effects of IR was tested.

纯度：≥98%

CAS：1638973-78-0