PF-6274484 is an irreversible (covalent) EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 of 5.8 nM and 6.6 nM, respectively. References:

纯度：≥98%

CAS：1035638-91-5