Piericidin A is an irreversible (covalent) inhibitor of mitochondrial complex I that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of the enzyme. Piericidin A induces transcription of the p53-responsive SESN2 gene which plays an important role in the stress response and homeostatic regulation. References: Imoto M. Chemistry and biology for the small molecules targeting characteristics of cancer cells. Biosci Biotechnol Biochem. 2018 Sep 24:1-10. doi: 10.1080/09168451.2018.1518704. [Epub ahead of print] PubMed PMID: 30247093.

纯度：≥98%

CAS：2738-64-9