AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG-221 decreased fed blood glucose and insulin levels and reduced body weight in diet-induced obesity mice. AMG 221 potently blocked 11β-HSD1 activity, producing sustained inhibition for the 24-hour study duration as measured in ex vivo adipose samples. Early characterization of concentration-response relationships can support rational selection of dose and regimen for future studies. References: Gao Q, Kimura RE, Zhang X, Nam J, Amore BM, Hickman D, Greg Slatter J, Emery MG. Intestinal and hepatic first-pass extraction of the 11β-HSD1 inhibitor AMG 221 in rats with chronic vascular catheters. Xenobiotica. 2014 Mar;44(3):264-9. doi: 10.3109/00498254.2013.769074. PubMed PMID: 23517558.

纯度：≥98%

CAS：1095565-81-3