PIH is an inhibitor of ciliogenesis through microtubule destabilization. It acts by antagonizing Hh signaling by repressing cilia biogenesis and disassembly of alpha tubulin in its stabilized form. References: Sinha S, Khatra H, Khan PP, Pattanayak S, Bhadra J, Rather B, Chakrabarti S, Saha T. Hedgehog antagonist pyrimidine-indole hybrid molecule inhibits ciliogenesis through microtubule destabilization. Chembiochem. 2018 Jan 24. doi: 10.1002/cbic.201700631. [Epub ahead of print] PubMed PMID: 29363254.

纯度：≥98%

CAS：441742-93-4