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PIP-199
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PIP-199图片
CAS NO:622795-76-0
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

PIP-199 is a novel, potent and selective inhibitor of protein-protein interaction between the RMI (RecQ-mediated genome instability protein) core complex and FANCM (a peptide referred to as MM2). Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies. Proper execution of the FA pathway requires interaction between the FA complementation group M protein (FANCM) and the RecQ-mediated genome instability protein (RMI) complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents. Inhibitors that block FANCM/RMI complex formation could be useful therapeutics for re-sensitizing tumors that have acquired chemotherapeutic resistance.

纯度:≥98%

CAS:622795-76-0