Ambroxol (NA-872), a metabolite of Bromhexine and a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus, is a novel and potent inhibitor of the neuronal Na+ channels, which inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Ambroxol inhibits Na+ channels in sensory neurons. The potency for tonic block of TTX-r channels is relatively high. Ambroxol affects the Na+ current kinetics of TTX-r and TTX-s channels differently.

纯度：≥98%

CAS：18683-91-5