Loreclezole (R-72063; R 72063; R72063), a triazole analog, is a sedative, anti-seizure/anticonvulsant and antiepileptic agent that acts as a positive allosteric modulator (PAM) of GABA_A receptor. Loreclezole has anti-seizure activity in a variety of seizure models, acting more like a barbiturate than a benzodiazepine in that the increase in seizure threshold produced by loreclezole was potentiated rather than blocked by the benzodiazepine antagonist, flumazenil, confirming that loreclezole does not interact with the benzodiazepine recognition site. In animal seizure models, loreclezole is protective against pentylenetetrazol seizures but is less active in the maximal electroshock test.

纯度：≥98%

CAS：117857-45-1