PNU-101017, formerly known as U-101017, is a gamma-aminobutyric acid (GABA) receptor agonist potentially for the treatment of anxiety. PNU-101017 has a high affinity for the GABAA receptor subtypes containing the alpha 1 and alpha 3 or alpha 5 subunits. PNU-101017 was weakly active in anti-conflict anxiolytic tests, but attenuated the plasma corticosteroid response to mild stress in rats. PNU-101017 did not potentiate the CNS-depressant effects of ethanol, and produced no evidence of physical dependence when administered repeatedly. References: Zhong WZ, Williams MG, Branstetter DG. Toxicokinetics in drug development: an overview of toxicokinetic application in the development of PNU-101017, an anxiolytic drug candidate. Curr Drug Metab. 2000 Nov;1(3):243-54. Review. PubMed PMID: 11465047.

纯度：≥98%

CAS：170568-47-5