AM-211 is a novel and highly potent antagonist of the prostaglandin D2 receptor type 2. AM-211 is active in animal models of allergic inflammation. AM211 has high affinity for human, mouse, rat, and guinea pig DP2 and it shows selectivity over other prostanoid receptors and enzymes. AM211 exhibits good orally bioavailable bioavailability in rats and dogs and dose-dependently inhibits 13,14-dihydro-15-keto-PGD(2)-induced leukocytosis in a guinea pig pharmacodynamic assay. References: Bain G, King CD, Brittain J, Hartung JP, Dearmond I, Stearns B, Truong YP, Hutchinson JH, Evans JF, Holme K. Pharmacodynamics, pharmacokinetics, and safety of AM21 a novel and potent antagonist of the prostaglandin D2 receptor type 2. J Clin Pharmacol. 2012 Oct;52(10):1482-93. Epub 2011 Nov 22. PubMed PMID: 22110163.

纯度：≥98%

CAS：1175526-27-8